cPCET versus HAT: A Direct Theoretical Method for Distinguishing X-H Bond-Activation Mechanisms

A versatile gold synthon for acetylene C-H bond activation.

The reaction of N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene gold hydroxide ([Au(OH)(IPr)]; 1) with acetylene and trimethylsilylacetylene derivatives cleanly leads to the formation of a gold-acetylide bond with the concomitant formation of water or trimethylsilanol. All compounds were isolated in high yield (>85%). The crystal structures of selected gold acetylides in conjunction with thei...

Laboratory Equivalents of C-h Bond Activation

INTRODUCTION Medicinal drugs act in the body by a variety of biochemical mechanisms. Depending on the types of functional groups found on the drug, the drug can react in one of the many compartments it passes through during metabolism. Some drugs are able to avoid side reactions, but there are some that are broken down or take effect in an undesired place. Prodrugs, inactive forms of drugs, are...

A versatile ruthenium catalyst for C-C bond formation by C-H bond activation.

1 “ Distinguishing direct versus indirect transcription factor - DNA interactions ”

P<P Published online August 3, 2009 in advance of the print journal. Open Access This manuscript is Open Access. Preprint Accepted likely to differ from the final, published version. Peer-reviewed and accepted for publication but not copyedited or typeset; preprint is service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this artic...

Rhodium-catalyzed olefination of aryl tetrazoles via direct C-H bond activation.

Rh(III)-catalyzed direct olefination reaction via aromatic C-H bond activation is described using tetrazole as the directing group. This reaction provides a straightforward way for the synthesis of ortho-alkenyl aryl tetrazoles. Various functional groups tolerate the reaction conditions and afford the corresponding products in moderate to excellent yields.